States
- Alaska
About Last Night... (mentioned)
- Arkansas
Something Wall-Mart This Way Comes It is also where the World Wide Recorder Concert
- Arizona
The Ungroundable (mentioned)
- California
Night of the Living Homeless Smug Alert! Coon vs. Coon & Friends Towelie AWESOM-O Butterballs I Should Have Never Gone Ziplining
- Colorado
Colorado is the state in which the fictional town of South Park is located. The state capital is Denver, which has been featured or mentioned quite a few times during the series. Other locations mentioned and visited include Fairplay, Evergreen and Greeley, among others. Fictional towns and cities located in Colorado include North Park, Middle Park and Beaverton. South Park is a real life geographical region in Colorado, but there is no actual town referred to as such in real life. The same is true of North Park and Middle Park. Connecticut Sheila's sister and her son Kyle Schwartz live in Connecticut.
- Hawaii
Butters and Kenny go to Hawaii, Butters' native land, in "Going Native".
- Kentucky
Cartman goes to Corbin, Kentucky to make a deal with Colonel Sanders about smuggling KFC in Colorado.
- Nebraska
The Cartman family comes from Nebraska. Kyle sent Ike to Nebraska in episode "Ike's Wee Wee".
- New Jersey
New Jersey overtakes half the country in "It's a Jersey Thing".
- New York
New York City appeared in a few episodes. The parents got to the Cartoon Central Network to protest Terrance and Phillip in "Death". Children from New York heckle the South Park children in "World Wide Recorder Concert". "Crab People that live under a TV station in New York, try and turn the worlds men "metrosexual" in order to enslave them in "South Park is Gay!". Kyle Broflovski's cousin Kyle Schwartz is from New York In "Pandemic 2: The Startling", New York is attacked by guinea pigs.
- Pennsylvania
Philadelphia and the Independence Hall are located in this state. The episode "Sexual Healing" partially takes part in this state.
- Utah
- Wisconsin
In the episode "How to Eat with Your Butt", Martha and Stephen Thompson, the couple with Reverse Polarity Syndrome, are from Wisconsin. In "Summer Sucks", Mr. Hat runs away to Green Bay, Wisconsin where he meets Brett Favre in the locker room of the Green Bay Packers.
- Wyoming