| Episodes | Original Air Date | # | |
|---|---|---|---|
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e01_480.jpg | Tonsil Trouble | ||
| After a routine tonsillectomy goes horribly wrong, Cartman comes face to face with his own mortality. | Mar 12, 2008 | 168 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e02_480.jpg | Britney's New Look | ||
| When the boys help Britney Spears get to the North Pole, they discover the shocking secret behind her popularity. | Mar 19, 2008 | 169 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e03_480.jpg | Major Boobage | ||
| In a South Park homage to the 1981 film, "Heavy Metal", the boys are trying to get Kenny off the latest drug craze that's captured the junior high and under set. | Mar 26, 2008 | 170 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e04_480.jpg | Canada on Strike | ||
| The head of the World Canadian Bureau leads the country into a long and painful strike and the responsibility of brokering a settlement rests with the boys. | Apr 2, 2008 | 171 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e05_480.jpg | Eek, A Penis! | ||
| While Ms. Garrison is off trying to find a way to become the man he was always intended to be, Cartman is put in charge of the classroom. | Apr 9, 2008 | 172 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e06_480.jpg | Over Logging | ||
| One day the citizens of South Park wake up and find the internet is gone. When Randy hears there may still be some internet out in California, he packs up his family and heads west. | Apr 16, 2008 | 173 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e07_480.jpg | Super Fun Time | ||
| While the kids are on an educational field trip to a living museum, Cartman makes Butters sneak away from the class to go to the amusement center located next door. | Apr 23, 2008 | 174 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e08_480.jpg | The China Probrem | ||
| With the rest of the American people haunted by the memory of a recent tragic event, only Butters will stand with Cartman as he confronts the Chinese. | Oct 8, 2008 | 175 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e09_480.jpg | Breast Cancer Show Ever | ||
| Wendy gets in trouble when she threatens to beat up Cartman after school. | Oct 15, 2008 | 176 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e10_480.jpg | Pandemic | ||
| While the world struggles to contain an epidemic of epic proportions, the boys find a way to make money off of it. | Oct 22, 2008 | 177 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e11_480.jpg | Pandemic 2: The Startling | ||
| Giant guinea pigs are attacking cities all over the world. The boys have the key that will save everyone from the onslaught but they're stranded in the Andes Mountains. | Oct 29, 2008 | 178 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e12_480.jpg | About Last Night... | ||
| While the country celebrates the outcome of the election, the new President-elect catches everyone off guard when he arrives at the White House prematurely. | Nov 5, 2008 | 179 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e13_480.jpg | Elementary School Musical | ||
| The boys must embrace the latest fad to hit South Park Elementary or risk their status as the coolest kids in school. | Nov 12, 2008 | 180 | |
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s12e14_480.jpg | The Ungroundable | ||
| Butters is sure he's seen a vampire at school but he can't get anyone to listen to him. Meanwhile, the Goth Kids are angry and frustrated when the other kids can't tell the difference between a Goth and a Vampire. | Nov 19, 2008 | 181 | |
